Serum mesothelin has a higher diagnostic utility than hyaluronic acid in malignant mesothelioma
نویسندگان
چکیده
منابع مشابه
Serum mesothelin has a higher diagnostic utility than hyaluronic acid in malignant mesothelioma.
UNLABELLED We assessed comparatively the diagnostic value of two potential malignant pleural mesothelioma (MPM) markers: hyaluronic acid (HA) and soluble mesothelin. MATERIALS AND METHOD We measured serum and pleural fluid values of mesothelin and hyaluronic acid in 76 patients with MPM, 33 patients with pleural metastases of carcinomas (Mets group) and 27 patients with benign pleural effusio...
متن کاملUtility of osteopontin and serum mesothelin in malignant pleural mesothelioma diagnosis and prognosis assessment.
PURPOSE Malignant mesothelioma is a highly aggressive tumor and is often diagnosed too late for a curative treatment. We compared diagnostic and prognostic values of mesothelin and osteopontin in 172 patients suspected of malignant pleural mesothelioma (MPM) and in a control group of 112 asymptomatic asbestos-exposed subjects. EXPERIMENTAL DESIGN Osteopontin and mesothelin were assayed with c...
متن کاملConcentration of hyaluronic acid in pleural fluid as a diagnostic aid for malignant mesothelioma.
Hyaluronic acid (HA) was determined with a radiometric assay in the serum and pleural fluid of 85 patients with pleural effusions, including 15 with malignant mesothelioma, 32 with other cancer, 31 with nonmalignant inflammatory diseases, and seven with congestive heart failure. With a cutoff level at 100 mg/L, the pleural fluid concentration of HA was raised in 73 percent of patients (11 of 15...
متن کاملHyaluronic acid content of effusions as a diagnostic aid for malignant mesothelioma.
A high-performance liquid chromatographic technique, using a size exclusion column (TSK-5000PW), has been developed for the quantification of hyaluronic acid (HA) in pleural and peritoneal effusions. Sample preparation requires only a 100-fold dilution of the exudate with phosphate buffer prior to analysis. Chromatographic conditions are: 0.05 M phosphate buffer (pH, 5.0) mobile phase at a flow...
متن کاملMesothelin-targeted immunotherapies for malignant pleural mesothelioma.
Despite the use of aggressive trimodality therapy consisting of neoadjuvant chemotherapy, surgery, and hemithoracic radiation, the median survival of patients with malignant pleural mesothelioma (MPM) is 12 to 18 months (1,2). Immune responses have been shown to be beneficial in MPM patients (3,4); therefore, focusing immunotherapeutic strategies on promoting these immune responses is an attrac...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Clinical Biochemistry
سال: 2009
ISSN: 0009-9120
DOI: 10.1016/j.clinbiochem.2009.03.007